厦门大学医学院导师介绍：许华曦

主要学术成果：

论文/著作/专利

1

Xu, H. ,Sweeney, D.,Wang, R., Thinakaran, G..,Lo,   A.C.Y., Sisodia, S., Greengard, P., and Gandy, S. (1997) Generation of   Alzheimer ß-amyloid Protein in the trans-Golgi Network in the Apparent   Absence of Vesicle Formation. Proc.   Natl. Acad. Sci. USA. （影响因子10.789） 94:3748-3752.

2

Xu, H., Gouras, G. K., Greenfield,   J. P., Vincent, B., Naslund, J., Mazzarelli, L., Jovanovic, J. N, Seeger, M,   Relkin, N. R, Liao, F., Checler, F., Buxbaum, J. D, Chait, B. T., Thinakaran,   G., Sisodia, S., Wang, R., Greengard, P., and Gandy, S. (1998). Estrogen   Reduces Neuronal Generation of Alzheimer ß-amyloid Peptides.  Nature   Medicine （影响因子27.905）4:447-451.

3

Greenfield, J. P., Tsai, J., Gouras, G. K., Hai,   B., Thinakaran, G., Checler, F., Sisodia, S. S., Greengard, P., and Xu, H.* (1999) Endoplasmic Reticulum   and trans-Golgi Network Generate Distinct Populations of Alzheimer ß-Amyloid   Peptides.  Proc. Natl. Acad. Sci. USA（影响因子10.789）96:742-747.

4

Gouras, G. K.¶, Xu, H.¶, Gross, R.,   Greenfield, J. P., Hai, B., Wang, R., and Greengard, P.  (2000) Testosterone Reduces Neuronal   Secretion of Alzheimer ß-amyloid Peptides.  Proc. Natl. Acad. Sci. USA （影响因子10.789）97:1202-1205.  (¶, equal contribution).   

5

Gasparini, L., Netzer, W., Greengard, P., and Xu, H*. (2002) Does Insulin Dysfunction Play a Role in   Alzheimer's Disease.  Trends in Pharmacological Sciences（影响因子13.276）23(6):288-293.

6

Dou, F., Netzer, W. J., Tanemura, K., Li, F.,   Hartl, F.U., Takashima, A., Gouras G.K., Greengard, P., and Xu, H.* (2003) Chaperones increase association of tau   protein with microtubules.  Proc. Natl. Acad. Sci. USA（影响因子10.789）100:721-726.

7

Gasparini, L and Xu, H.* (2003) Potential   roles of insulin and IGF-1 in Alzheimer's disease. Trends in Neurosciences（影响因子16.475）26(8):404-406.

8

Zhang, Y.W., Wang, R., Liu,   Q., Zhang, H., Liao, F.F., Xu, H.* (2007)   Presenilin/ g-secretase- dependent   processing of APP regulates EGFR expression. Proc Natl Acad Sci USA (影响因子10.789)104: 10613-10618.

9

Zhang, Y.W., Liu, S., Zhang,   X., Li, W.B., Chen, Y., Huang, X., Sun, L., Luo, W., Netzer, W.J., Threadgill,   R., Wiegand, G., Wang, R., Cohen, SN., Greengard, P., Liao, F.F., Li, L., Xu, H..* (2009) A functional mouse retroposed gene Rps23r1 reduces   Alzheimer’s b-amyloid levels and tau   phosphorylation. Neuron (影响因子14.17)  64：328-340.

10

Zhang, Y-w., Xu,   H. * (2010) Substrate check of gamma-secretase. Nat Struct Mol Biol（影响因子12.273）17(2):140-141.

11

Chen, Y., Huang, X., Zhang, YW., Rockenstein, E., Bu, G., Golde, T.E., Masliah, E., Xu, H. * (2012)Alzheimer's   β-secretase (BACE1) regulates the cAMP/PKA/CREB pathway independently of   β-amyloid. J Neurosci（影响因子7.271）32(33):11390-11395.

12

Zhang, H., Zhang, Y.W., Chen, Y., Huang, X., Zhou, F., Wang, W., Xian, B., Zhang, X., Masliah, E., Chen, Q., Han, J.D., Bu, G., Reed, J.C., Liao, F.F., Chen, Y.G., Xu, H. * (2012)Appoptosin is   a Novel Pro-Apoptotic Protein and Mediates Cell Death in Neurodegeneration. J Neurosci（影响因子7.271）32(44):15565-15576.

13

Wang, X., Zhao, Y., Zhang, X., Badie, H., Zhou, Y., Mu, Y., Loo, L.S., Cai, L., Thompson, R.C., Yang, B., Chen, Y., Johnson, P.F., Wu, C., Bu, G., Mobley, W.C., Zhang, D., Gage, F.H., Ranscht, B., Zhang, Y.W., Lipton, S.A., Hong, W., Xu, H. * (2013) Loss of   sorting nexin 27 contributes to excitatory synaptic dysfunction by modulating   glutamate receptor recycling in Down’s syndrome. Nat Med（影响因子22.462）19(4):473-480.

14

Wang, X., Huang, T.,   Zhao, Y., Zheng, Q., Thompson, R.C., Bu, G., Zhang, Y.W., Hong, W., Xu, H. * (2014) Sorting nexin 27 regulates Aβ production through modulating γ-secretase activity.   Cell Rep（影响因子7.207）9(3):1023-1033.

15

Zhao, Y., Tseng, I.C.,   Heyser, C.J., Rockenstein, E., Mante, M., Adame, A., Zheng, Q., Huang, T.,   Wang, X., Arslan, P.E., Chakrabarty, P., Wu, C., Bu, G., Mobley, W.C., Zhang,   Y.W., St George-Hyslop, P., Maslia,h E., Fraser, P., Xu, H. * (2015) Appoptosin-Mediated Caspase Cleavage of Tau   Contributes to Progressive Supranuclear Palsy Pathogenesis. Neuron (影响因子15.054)  87(5):963-75.

主要课题

项目名称

来源

经费

起止日期

SNX27在海马神经环路中的功能和在唐氏综合症认知障碍发生过程中的作用

国家自然科学基金国家基金重大研究计划

80万元

2014-2016

阿尔茨海默病中APP蛋白的转运调控研究

国家自然科学基金促进海峡两岸科技合作联合基金

256万元

2015-2018

SORLA通过EphA4抑制Aβ神经毒性的研究

国家自然科学基金面上项目

54万元

2018-2021

主要获奖/荣誉称号

获奖项目

授予单位

获奖时间

中国国家基金委杰出青年（海外）奖

中国国家自然科学基金委

2003

2012年度福建省自然科学奖二等奖

福建省人民政府

2013