厦门大学生命科学学院导师介绍：左正宏

  左正宏ZUO Zhenghong, Ph.D.
  教授  博士生导师
  电话：+86-592-2187353
  E-mail：zuozhenghong@xmu.edu.cn
  安徽师范大学学士（1996）；
  厦门大学理学硕士（1999）；
  厦门大学理学博士（2005）；
  纽约大学医学院访问学者（2009）；
  2005年至今为厦门大学生命科学学院助理教授、副教授、教授。
  1996, BSc., Anhui Normal University; 1999, MSc., Xiamen University; 2005, Ph.D., Xiamen University; 2009, Research Scholar, New York University. 2005-Present, Assist. Professor, Assoc. Professor, Professor, School of Life Sciences, Xiamen University.
  20110118084719527研究领域（Research Area）
  主要从事持久性有机污染物(如多环芳烃、有机锡、多氯联苯、六溴环十二烷等)对动物的生殖、发育和神经等毒性效应及其分子机制；寻找能应用于环境污染物检测和风险评价的生物标志物。
  Our research focuses on 1) Reproductive, developmental and neural toxic effect of organic pollutants such as polycyclic aro-matic hydrocarbon, polychlorinated biphenyls, organotins on animals (fish and mammal) and its mechanism, 2) Correlative bio-markers to monitor the pollutions and to assess the risks.
  代表性论文（Selected Publications）(*为通讯作者）
  1.Huang, L.X., Xi, Z.H., Wang, C.G., Zhang, Y.Y., Yang, Z.B., Zhang, S.Q., Zuo, Z.H.* 2016. Phenanthrene exposure induces cardiac hypertrophy via reducing miR-133a expression by DNA methylation. Scientific reports, 6:20105.
  2.Wu, M.F., Wu, D., Wang, C.G., Guo, Z.Z., Li, B.W., Zuo, Z. H.* 2015. Hexabromocyclododecane exposure induces cardiac hypertrophy and arrhythmia by inhibiting miR-1 expression via up-regulation of the homeobox gene Nkx2.5. Journal of hazardous materials, 302:304-313.
  3.Gao, D.X., Wu, M.F., Wang, C.G., Wang, Y.C., Zuo, Z. H.* 2015. Chronic exposure to low benzo[a]pyrene level causes neurodegenerative disease-like syndromes in zebrafish (Danio rerio). Aquatic Toxicology, 167:200-208.
  4.Zhang, S.Q., Wu, T., Chen, M., Guo, Z.Z., Yang, Z.B., Zuo, Z. H.,* Wang, C.G.* 2015. Chronic exposure to Aroclor 1254 disrupts glucose homeostasis in male mice via inhibition of the insulin receptor signal pathway. Environmental Science & Technology, 49(16):10084-10092.
  5.Zuo, Z.H., Wu, T., Lin, M.D., Zhang, S.Q., Yan, F.H., Yang, Z.B., Wang, Y.C., Wang, C.G.* 2014. Chronic exposure to tributyltin chloride induces pancreatic islet cell apoptosis and disrupts glucose homeostasis in male mice. Environmental Science & Technology, 48(9):5179-5186.
  6.Zuo, Z.H., Che, X., Wang, Y.L., Li, B.W., Li, J.X., Dai, W.X., Lin, C.P., Huang, C.S.* 2014. High mobility group Box-1 inhibits cancer cell motility and metastasis by suppressing activation of transcription factor CREB and nWASP expression. Oncotarget, 5(17):7458-7470.
  7.Huang, L.X., Gao, D.X., Zhang, Y.Y., Wang, C.G., Zuo, Z. H.* 2014. Exposure to low dose benzo[a]pyrene during early life stages causes symptoms similar to cardiac hypertrophy in adult zebrafish. Journal of Hazardous Materials, 276:377-382.
  8.Cai, J.L., Wang, C.G., Huang, L.X, Chen, M., Zuo, Z. H.* 2013. A novel effect of polychlorinated biphenyls: impairment of the tight junctions in the mouse epididymis. Toxicological Sciences, 134(2):382-390.
  9.Huang, L.X., Wang, C.G., Zhang, Y.Y., Wu, M.F., Zuo, Z. H.* 2013. Phenanthrene causes ocular developmental toxicity in zebrafish embryos and the possible mechanisms involved. Journal of Hazardous Materials, 261:172-180.
  10.Zuo, Z. H., Cai, T.J., Li, J.X., Zhang, D.Y., Yu, Y.H., Huang, C.S.* 2012. Hexavalent Chromium Cr(VI) Upregulates COX-2 Expression through an NFκB/c-Jun/AP-1-dependent Pathway. Environmental Health Perspectives, 120(4):547-553.
  11.Zuo, Z. H.*, Wang, C.G., Wu, M.F., Wang, Y.Q., Chen, Y.X. 2012. Exposure to Tributyltin and Triphenyltin induces DNA damage and alters nucleotide excision repair gene transcription in Sebastiscus marmoratus liver. Aquatic Toxicology, 122-123:106-112.
  12.Zuo, Z. H., Ouyang, W.M., Li, J.X., Costa, M., Huang, C.S.* 2012. Cyclooxygenase-2 (COX-2) Mediates Arsenite Inhibition of UVB-induced Cellular Apoptosis in Mouse Epidermal Cl41 cells. Current Cancer Drug Targets, 12(6):607-616.
  13.Huang, L.X., Wang, C.G., Zhang, Y.Y., Li, J., Zhong, Y.F., Chen, Y.X., Zuo, Z. H.* 2012. Benzo[a]pyrene exposure influences the cardiac development and the expression of cardiovascular relative genes in zebrafish (Danio rerio) embryos. Chemosphere, 87（4）:369-375.
  14.He, C.Y., Wang, C.G., Zhou, Y.L., Li, J., Zuo, Z. H.* 2012. Embryonic exposure to benzo(a)pyrene influences neural development and function in rockfish (Sebastiscus marmoratus). Neurotoxicology, 33(4):758-762.
  15.Zhang, Y.Y., Wang, C.G., Huang, L.X., Chen, R., Chen, Y.X., Zuo, Z. H.* 2012. Low-level pyrene exposure causes cardiac toxicity in zebrafish (Danio rerio) embryos. Aquatic Toxicology, 114-115:119-124.
  16.Cai, J.L., Wang, C.G., Wu, T., Zhong, Y.F., Huang, X., Zuo, Z. H.* 2011. Disruption of spermatogenesis and differential regulation of testicular estrogen receptor expression in mice after polychlorinated biphenyl exposure. Toxicology, 287(1-3): 21-28.
  荣誉、奖励（Honors and award）
  “坛紫菜新品种选育、推广及深加工技术”，第三完成者，2011年获国家科学技术进步奖二等奖。
  “有机锡的毒性效应与机制及其在生态风险评价中的应用”，第二完成者，2014年获厦门市科学技术进步奖三等