厦门大学药学院导师介绍：吕忠显

  吕忠显博士、教授、博士生导师
  个人简介：
  福建省高等学校新世纪优秀人才。曾获厦门大学 “清源”、“鹭燕”科教奖。2006年担任加利福尼亚大学Irvine分校医学院助理研究员，2007年7月，以厦门大学“985”平台重点引进人才任厦门大学教授、代谢性疾病研究中心执行主任。目前是中国动物学会生殖生物学分会常务理事，北美生殖生物学、美国癌症研究协会、中国细胞生物学会、中国生理学会会员。现任代谢性疾病厦门市重点实验室主任、“生殖调控与生殖健康研究”福建省高校重点实验室副主任。
  主要从事性腺发育与不孕不育、糖脂代谢疾病、肝癌及乳腺癌的基因调控研究，以发现和鉴别原创性分子治疗靶点，研发针对这些分子靶点的靶向药物。已在PNAS、J Mole Cell Biol、Oncogene、J BiolChem、Scientific Reports等国际一流杂志上发表多篇论文，并获得四项发明专利。获得国家重大科学研究计划项目（科技部973计划）课题（2013CB945503、2010CB945004）、科技部重点研发计划重点专项课题（SQ2017YFSF080005-02）、国家自然科学基金（31671564、81470111、31171375、30772546）、福建省卫教联合公关项目、厦门市科技项目等多项课题资助。
  目前主要研究方向：
  1、代谢性疾病的分子机制及靶向药物研发
  2、生殖器官的发育及疾病
  3、肝癌的基因调控
  近期主要科研论文 (* corresponding author)
  1.Jianghong Cheng#, YanhongZhong#, Shuai Chen#, Yan Sun, Lantang Huang, YujiaKang, Baozhen Chen, Gang Chen, Fengli Wang, YingpuTian, Wenjie Liu, Gen-ShengFeng, and Zhongxian Lu.*Gab2 mediates hepatocellular carcinogenesis by integrating multiple signalingpathways. FASEB J 2017 Aug 21doi: 10.1096/fj.201700120RR.
  2.Hao Ran#, Shuangbo Kong#，Shuang Zhang#, JianghongCheng,ChanZhou，Bo He，Qiliang Xin, John P Lydon, Francesco J DeMayo, Gen-Sheng Feng,GuoliangXia, ZhongxianLu*, Chao Wang*, Haibin Wang*. Nuclear Shp2 directs normal embryo implantation via facilitating the ERα tyrosine phosphorylation by the Src kinase.ProcNatlAcadSci U S A. 2017,114(18):4816-4821May 2. doi: 10.1073/pnas.1700978114
  3.Jin Tao, Lianping Zheng，MinghuiMeng, Yanli Li, Zhongxian Lu*. Shp2 suppresses the adipogenic differentiation of preadipocyte 3T3-L1 cells at the early stage.Cell Death Discovery, 2016, 2:16051; doi:10.1038
  4.Shuai Chen#, Yujia Kang#, Yanli Li, Jin Tao, Baozhen Chen, Gang Chen, Yang Li,YingpuTian, Yinan Zhao, jianghong Cheng,Wenjie Liu, Gen-Sheng Feng*, Zhongxian Lu*. Deletion of Gab2 in mice protects against hepatic steatosis and steatohepatitis: a novel therapeutic target for fatty liver diseases.Journal of Molecular Cell Biology，2016, 8(6), 492–504
  5.Xiaopeng Hu#, Zhenzhou Tang#, Yang Li#, Wensheng Liu, Shuang Zhang, Bingyan Wang, YingpuTian, Yinan Zhao, Hao Ran, Wenjie Liu, Gen-Sheng Feng, Martin M. Matzuk, JianweiShuai , Haibin Wang*，Zhongxian Lu*. Deletion of the tyrosine phosphatase Shp2 inSertoli cells causes infertility in mice. Scientific Reports, 2015 Aug 12;5:12982. doi: 10.1038/srep12982
  6.Xuan Zhuang#, Zhiming Li#, Huinuan Lin, Long Gu, Qing Lin, Zhongxian Lu*, and Chi-mengTzeng*. Integrated miRNA and mRNA expression profiling to identify mRNA targets of dysregulatedmiRNAs in non-obstructive azoospermia.Scientific Reports, 2015, Jan 28;5:7922. doi: 10.1038/srep07922
  7.Wenqing Huang#, Qing Lin#, Xuan Zhuang, LiangliangCai, RunshengRuan, Zhongxian Lu*, ChingmengTzeng*.Structure,Function, and Pathogenesis of SHP2 in Developmental Disorders and Tumorigenesis. Current Cancer Drug Targets. 2014，14(6):567-88
  8.Jun Li#, Yujia Kang#, Longgang Wei, Wenjie Liu, YingpuTian, Baozhen Chen, Xiandonglin, Yang Li, Gensheng Feng, Zhongxian Lu*.Tyrosine phosphatase Shp2 mediates the estrogen biological action in breast cancer via interaction with the estrogen extranuclear receptor. Plos One, 2014; 9(7):e102847
  9.Suman Verma#,Michael L. Salmans#, Mikhail Geyfman, Hong Wang, Zhengquan Yu, Zhongxian Lu, Fang Zhao, Steven M. Lipkin, Bogi Andersen*. The estrogen-responsive Agr2 gene regulates mammary epithelial proliferation and facilitates lobuloalveolar development. Developmental Biology, 2012, 369(2):249-60
  10.Jie Wu#, Chi Wang#, Xilan Li, Yanling Song, Wei Wang, Cong Li, Jia Hu, Zhi Zhu, Jiuxing Li,Weiyun Zhang, Zhongxian Lu* and Chaoyong James Yang*. Identification, Characterization and Application of a G-Quadruplex Structured DNA Aptamer against Cancer Biomarker Protein Anterior Gradient Homolog 2. Plos One, 2012, 7(9):e46393. doi: 10.1371
  11.Dongping Liu#,Guiping Kong#,QuanChengChen,Guanghui Wang,Jie Li,Yang Xu, Ting lin, YingpuTian, Xiaokun Zhang, Xinsheng Yao, Gensheng Feng, Zhongxian Lu*and Haifeng Chen*. Fatty acids asnatural specific inhibitors of the proto-oncogenic protein Shp2.Bioorganic & Medicinal Chemistry Letters, 2011，21:6833-6837.
  12.Jia Hu, Jie Wu, Cong Li, Ling Zhu, Weiyun Zhang,Guiping Kong，Zhongxian Lu*,Chaoyong Yang*. A G-aquadruplexaptamer inhibits the phosphatase activity of oncogenic protein shp2. Chembiochem, 2011, 12(3):424-30.
  13.Yanyan Bu#, Tao Shi#, MinghuiMeng#, Guiping Kong, YingpuTian,Quancheng Chen, Gensheng Feng, Xinsheng Yao,Haifeng Chen* and Zhongxian Lu*. A novel screening model for molecular drug for diabetes and obesity based on the tyrosine phosphatase Shp2. Bioorganic & Medicinal Chemistry Letters 2011，21: 874-878
  14.YingpuTian#, Ning Wang# and Zhongxian Lu*. Repression of Lmo4 activated transcription inhibits proliferation and induces apoptosis of normal mammary epithelial cells and breast cancer cells.Clinical & Experimental Metastasis， 2010，27（7）：455-463
  招聘：欢迎兴趣相投的助理教授、博士后、博士及硕士研究生加盟。
  地址：福建省厦门市翔安区翔安南路厦门大学药学院
  邮编：361102
  电话：0592-2187227
  电子邮箱:zhongxian@xmu.edu.cn