厦门大学药学院导师介绍：李福男

  李福男博士、副教授
  个人简历：
  李福男，男，博士，副教授，硕士研究生导师。2010年4月回国就职，从事药物化学的教学和科研工作，主讲本科生及研究生的《药学导论》、《药物合成反应》、《药物化学》、《药物化学实验》、《药物化学研究进展》等课程。Medicinal Chemistry Research, Bioorganic & Medicinal Chemistry杂志审稿人。现主要研究方向为创新药物分子的设计、合成及机制研究，药物合成工艺及产业化研究。
  教育、工作背景：
  1991.9-1995.7 延边大学药学院药学专业学士
  1999.9-2002.7 延边大学药学院药物化学硕士
  2005.2-2010.2 韩国首尔大学药学院药物化学博士、博士后
  2010.4-至今厦门大学药学院药物化学与信息学副教授
  主要研究方向：
  1、TRPV1受体拮抗剂的设计、合成及镇痛活性研究；
  2、喹啉衍生物的设计、合成及抗癫痫活性研究；
  3、VEGF/ VEGFR为靶点的肝癌药物设计、合成及活性研究；
  4、Nur77-LKB1-AMPK为靶点的新型糖尿病药物设计、合成及活性研究；
  5、药物合成工艺及产业化研究。
  研究成果：
  近年来主持或参与承担国家自然科学基金项目、省科技厅自然科学基金重点和面上项目、制药企业课题等多项研究工作。在国内外学术期刊上发表论文20多篇，其中SCI收载论文22篇。国际发明专利授权1项，申请国内专利2项。
  通讯或第一作者论文及专利：
  1、Shao-MeiYang, Zhi-NingHuang, Zhong-Shi Zhou, Jin Hou, Man-Yi Zheng, Li-Juan Wang, Yu Jiang, Xin-Yi Zhou, Qiu-Yue Chen, Shan-Hua Li, Fu-Nan Li.*Structure-based design, structure-activity relationship analysis, and antitumor activity of diaryl ether derivatives. Arch Pharm Res.,2015, in press.（*corresponding author)
  2、Jin Hou,Wei Zhao, Zhi-NingHuang, Shao-MeiYang, Li-Juan Wang, Yu Jiang, Zhong-Shi Zhou, Man-Yi Zheng, Ji-Li Jiang, Shan-Hua Li, and Fu-Nan Li.*Evaluation of novel N-(piperidin-4-yl) benzamide derivativesas potential cell cycle inhibitors in HepG2 cells. Chemical Biology & Drug Design, 2014, in press.（*corresponding author)
  3、Shi-Ben Wang, Peng Jin, Fu-Nan Li*, Zhe-Shan Quan*. Synthesis and anticonvulsant activity of novel purine derivatives. Eur J Med Chem., 2014, 84,574-583.（*corresponding author)
  4、Young Taek Han, Shao-Mei Yang, Xiao-Yuan Wang, and Fu-Nan Li.* Design, Synthesis and Biological Evaluation of B-Region Modified Diarylalkyl Amide Analogues as Novel TRPV1 Antagonists. Arch Pharm Res.,2014, 37 (4) 440-451.（*corresponding author)
  5、Nam-Jung Kim,*Fu-Nan Li,*  Jin Hee Lee, Seul-gi Park, Kyeojin Kim, Changjin Lim, Young Taek Han,  Hwayoung Yun, Jong-Wha Jung, Hyeung-geun Park, Hee-Doo Kim, Byoung Young  Woo, Song Seok Shin, Sun-Young Kim, Jin Kyu Choi, Yeon-Su Jeong,  Yanghui Park, Young-Ho Park, Dae-Duk Kim, Sun Choi, and Young-Ger Suh.  Heterocycle-linked Phenylbenzyl Amides as Novel TRPV1 Antagonists and  Their TRPV1 Binding Modes: Constraint-Induced Enhancement of in Vitro and in Vivo Activities. Chemistry-an Asian Journal, 2013, 8(2):400-409. (*these authors contributed this work equally)
  6、Xian-Qing Deng, Ming-Xia Song, Cheng-Xi Wei, Fu-Nan Li,* Zhe-Shan Quan*. Synthesis and Anticonvulsant Activity of 7-Alkoxy-Triazolo-[3, 4-b] Benzo[d]Thiazoles. Medicinal Chemistry, 2010,6(5):313-320. （*corresponding author)
  7、Fu-Nan Li, Nam-Jung Kim, Dong-Jo Chang, Jaebong Jang, Hannah Jang, Kyung-Hoon Min, Yeon-Su Jeong, Sun-Young Kim, Young-Ho Park,Hee-Doo Kim, Hyeung-Geun Park, Young-Ger Suh. Synthesis and Structural Optimization of Multiple H-bonding Region of Diarylalkyl (Thio)Amides as NovelTRPV1 Antagonists. Bioorg. Med. Chem., 2009, 17(24), 8149-8160.
  8、Fu-Nan Li, Nam-Jung Kim, Yeon-Hee Nam, Seung-Hee Kim,Seung-Yong Seo, Yeon-Su
  Jeong, Sun-Young Kim, Young-Ho Park,and Young-Ger Suh. Design, synthesis, and biological evaluation of phenylpropanamides as novel transient receptor potential vanilloid 1
  antagonists.Arch Pharm Res.,2009, 32 (9) 1201-1210.
  9、Fu-Nan Li, Nam-Jung Kim, Seung-Mann Paek, Do-Yeon Kwon, Kyung-Hoon Min, Yeon-Su
  Jeong, Sun-Young Kim, Young-Ho Park,Hee-Doo Kim, Hyeung-Geun Park, and
  Young-Ger Suh. Design, synthesis, and biological evaluation of novel diarylalkyl amides as
  TRPV1 antagonists.Bioorg. Med. Chem., 2009, 17(10), 3557-3567.
  10、NOVEL  COMPOUNDS, ISOMER THEREOF, OR PHARMACEUTICALLY ACCEPTABLE SALTS THEREOF  AS VANILLOID RECEPTOR ANTAGONIST AND PHARMACEUTICAL COMPOSITIONS  CONTAINING THE SAME, 国际专利：WO2010002209 A3
  11、李福男，李善花，朱铉，侯瑾，杨少梅，黄志宁，周仲实. 4-苯氧基苯甲酰胺类化合物及其制备方法和应用。申请号：201410006558.0 公开/公告号：CN103709094A
  12、李福男，李善花，王利娟，杨少梅，侯瑾，黄志宁，郑满意，姜吉利，陈秋月. 一种取代二芳醚类化合物及其制备方法及应用。申请号：201410232271.X公开/公告号：CN104163772A
  联系方式：
  地址：福建省厦门市翔安区翔安南路，厦门大学药学院
  Email: fnlee5@xmu.edu.cn