厦门大学药学院导师介绍：李明玉

  个人简介：
  李明玉博士主要研究方向为糖尿病疾病机理及药物开发、高通量药物筛选、海洋药物的筛选和作用机理等研究工作。围绕体内外的糖尿病疾病模型，应用高通量药物筛选技术、组学技术、现代分子生物学技术等手段，在糖尿病疾病模型建立、分子机理研究及先导药物的开发研究等方面取得了多项研究进展。至今在Cell Metabolism, Trends in Genetics, Diabetes, Journal of Endocrinology等国际主流杂志共发表文章二十多篇。现为Frontiers in Endocrinology、药学研究等刊物编委，受邀为Scientific Reports、Plos One、General and Comparative Endocrinology 等十多个杂志审稿人。目前主持国家自然基金面上项目、福建省自然基金面上项目、厦门大学校长基金等多个项目。并曾参与多项国家自然科学基金、美国NIH、美国糖尿病协会等项目的研究工作。同美国范德堡大学、美国密歇根大学、英国卡迪夫大学等国际著名高校的相关实验室建立了良好的合作研究关系。
  教育与工作经历：
  1999-2003中国海洋大学本科（生物技术）
  2003-2006中国海洋大学硕士（细胞生物学）
  2006-2010中国海洋大学博士（药物化学）
  2010-2011国家海洋局第三海洋研究所助理研究员
  2011-2016美国范德堡大学（Vanderbilt University）博士后
  2016-至今厦门大学药学院副教授
  主要研究方向：
  1、胰岛α和β-细胞增生的分子机理。
  2、糖尿病模型的构建及抗糖尿病药物的筛选。
  3、斑马鱼疾病模型的建立及药物筛选。
  4、海洋药物筛选及作用机理。
  5、高通量药物筛选技术。
  6、CRISPR基因组编辑技术。
  代表性论文
  E. Danielle Dean, Mingyu Li, Nripesh Prasad, Scott N. Wisniewski, Alison Von Deylen, Jason Spaeth, Lisette Maddison, Anthony Botros, Leslie R. Sedgeman, NadejdaBozadjieva, Olga Ilkayeva, Anastasia Coldren, Greg Poffenberger, Alena Shostak, Michael C. Semich, Kristie I. Aamodt, Neil Phillips, Hai Yan, Ernesto Bernal-Mizrachi, Jackie D. Corbin, Kasey C. Vickers, Shawn Levy, Chunhua Dai, Christopher Newgard, Wei Gu, Roland Stein, Wenbiao Chen, and Alvin C. Powers. Interrupted Glucagon Signaling Reveals a Hepatic-α-Cell Axis and a Role for L-Glutamine in Stimulating α-Cell Proliferation. Cell Metabolism.2017 Jun 6;25(6):1362-1373
  Mingyu Li#, Liyuan Zhao#, Patrick Page-McCaw, Wenbiao Chen. Zebrafish genome engineering using the CRISPR-Cas9 system. Trends Genet. 2016 Dec;32(12):815-827.
  Mingyu Li, Patrick Page-McCaw,Wenbiao Chen. FGF1 mediates overnutrition-induced compensatory β-Cell differentiation in zebrafish. Diabetes. 2016, 65(1):96-109.
  Mingyu Li, Danielle Dean, Liyuan Zhao, Wendell E. Nicholson, Alvin C. Powers, Wenbiao Chen. Glucagon receptor inactivation leads to α-cell hyperplasia in zebrafish. J Endocrinol, 2015, 227 (2) 93-103.
  Mingyu Li, Lisette A Maddison, Patrick Page-McCaw, Wenbiao Chen. Overnutrition induces β-cell differentiation through prolonged activation of β-cells in zebrafish larvae. Am J PhysiolEndocrinolMetab. 2014, 306(7): E799-807.
  Mingyu Li, Qiuhua Li, Zhijun Yang, Guohai Hu, Ting Li, Xinhua Chen, JingqunAo. Identification of Cathepsin B from large yellow croaker (Pseudosciaenacrocea) and its role in the processing of MHC class II-associated invariant chain. Dev Comp Immunol. 2014, 45(2):313-320.
  Mingyu Li, Lisette A. Maddison, Zachary Crees, Wenbiao Chen.Targeted overexpression of CKI-insensitive cyclin-dependent kinase 4 increases functional β-cell number through enhanced self-replication in zebrafish. Zebrafish. 2013 Jun;10(2):170-6.
  Mingyu Li, Yang Ding, Yinnan Mu, JingqunAo, Xinhua Chen*.Molecular cloning and characterization of caspase-3 in large yellow croaker (Pseudosciaenacrocea). Fish & Shellfish Immun. 2011, 30 (3):910-916.
  Mingyu Li, Yun Li, Ling Lu, Xianlei Wang, Qingli Gong, Cunming Duan*. Structural, gene expression, and functional analysis of the fugu (Takifugurubripes) insulin-like growth factor binding protein-4 gene. Am J Physiol Regulatory Integrative Comp Physiol 2009, 296(3): 558-566.
  Yinnan Mu#, Mingyu Li#, Feng Ding#, Yang Ding, JingqunAo, Songnian Hu, Xinhua Chen. De Novo Characterization of the Spleen Transcriptome of the Large Yellow Croaker (Pseudosciaenacrocea) and Analysis of the Immune Relevant Genes and Pathways Involved in the Antiviral Response.PLoS One. 2014, 9(5):e97471.(# Co-first author).
  Xiaoqiang Xiao#, Mingyu Li#, Kunru Wang#, Qiwei Qinand Xinhua Chen*. Characterization of large yellow croaker (Pseudosciaenacrocea) β-actin promoter supports β-actin gene as an internal control for gene expression modulation and its potential application in transgenic studies in fish.Fish & Shellfish Immun. 2011, 30(4-5):1072-1079.(# Co-first author).
  Tingjun Fan*, Mingyu Li, Jing Wang, Lingling Yang, Rishan Cong. Purification and Characterization of Phenoloxidase from Octopus ocellatus. Acta Biochim Biophys Sin2009,41(10):865-872.
  Gaurav K Varshney, Wuhong Pei, Matthew C. LaFave, Jennifer Idol, Lisha Xu, Viviana Gallardo, Blake Carrington, Kevin Bishop, Marypat Jones, Mingyu Li, Ursula Harper, Sunny Huang, Wenbiao Chen, Raman Sood, Johan Ledin, and Shawn M. Burgess. High-Throughput Gene targeting and phenotyping in Zebrafish Using CRISPR/Cas9. Genome Res. 2015 Jul; 25(7): 1030-1042.
  Linlin Yin, Lisette A Maddison, Mingyu Li, Nergis Kara, Mathew C Lafave, Gaurav K Varshney, Shawn M Burgess, James G Patton and Wenbiao Chen. Multiplex conditional mutagenesis using transgenic expression of cas9 and sgRNAs.Genetics. 2015 Jun;200(2):431-41.
  Jingqun Ao, Yinnan Mu, Li-Xin Xiang, DingDing Fan, MingJi Feng, Shicui Zhang, Qiong Shi, Lv-Yun Zhu, TingLi, Yang Ding, Li Nie, Qiuhua Li, Wei-ren Dong, Liang Jiang, Bing Sun, XinHui Zhang, Mingyu Li, Hai-QiZhang, ShangBo Xie, YaBing Zhu, XuanTing Jiang, Xianhui Wang, Pengfei Mu, Wei Chen, Zhen Yue, ZhuoWang, Jun Wang, Jian-Zhong Shao, Xinhua Chen. Genome sequencing of the perciform fish Larimichthyscrocea provides insights into stress adaptation.PLoS Genet, 2015, 11(4): e1005118.
  Lisette A. Maddison, Mingyu Li, Wenbiao Chen. Conditional Gene-Trap Mutagenesis in Zebrafish. Methods Mol Biol. 2014;1101:393-411.
  Xianlei Wang, Ling Lu, Yun Li, Mingyu Li, Qiang Feng, Chen Chen, Cunming Duan*. Structural, Comparative Genomics, Gene Expression, and Functional Analysis of Two Distinct Zebrafish IGF Binding Protein-6 Genes. Am J Physiol Regulatory Integrative Comp Physiol2009,296(5):1348-1357.
  联系方式：
  地址：福建省厦门市翔安区翔安南路厦门大学药学院
  Email：limingyu@xmu.edu.cn