南京农业大学食品科技学院导师介绍：冯治洋

 

姓名：	冯治洋	学历：
职称：	教授	职务：
部门：	生物工程	邮件：	zfeng@njau.edu.cn
办公电话：	025-84399511	办公地址：	食品院205
研究方向：	微生物宏基因组学、天然产物生物合成

　　教学情况：
　　主持研究生课程<生物技术药物进展>

　　科研情况：
　　2006 年博士毕业于日本名古屋大学,2006年至2012年先后在美国威斯康星大学麦迪逊分校和洛克菲勒大学做博士后研究，2012年受聘为南京农业大学食品科技学院教授。已在PNAS, JACS等期刊上发表SCI论文15篇。
　　Huang SX﹟, Feng Z﹟, Wang L﹟, Galm U, Wendt-Pienkowski E, Yang D, Tao M, Coughlin JM, Duan Y, Shen B (2012) A designer bleomycin with significantly improved DNA cleavage activity. J Am Chem Soc, 134:13501-13509. (﹟ co-first author)
　　Feng Z, Chakraborty D, Dewell S, Reddy BV, Brady SF (2012) Environmental DNA encoded antibiotics fasamycin A and B inhibit FabF in type II fatty-acid biosynthesis. J Am Chem Soc, 134:2981–2987.
　　Iqbal HA, Feng Z, Brady SF (2012) Biocatalysts and small molecule products from metagenomic studies. Curr Opin Chem Biol, 16:109-16.
　　Reddy BV, Kallifidas D, Kim JH, Charlop-Powers Z, Feng Z, Brady SF (2012) Natural product biosynthetic gene diversity in geographically distinct soil microbiomes. Appl Environ Microbiol, 78:3744-52.
　　Feng Z, Kallifidas D, Brady SF (2011) Functional analysis of environmental DNA-derived Type II polyketide synthases reveals structurally diverse secondary metabolites. Proc Natl Acad Sci USA, 108:12629-12634.
　　Biggins JB, Liu X, Feng Z, Brady SF. (2011) Metabolites from the Induced Expression of Cryptic Single Operons Found in the Genome of Burkholderia pseudomallei. J Am Chem Soc, 133:1638-1641.
　　Yang D, Zhu X, Wu X, Feng Z, Huang L, Shen B, Xu Z. (2011) Titer improvement of iso-migrastatin in selected heterologous Streptomyces hosts and related analysis of mRNA expression by quantitative RT-PCR. Appl Microbiol Biotechnol, 89:1709-1719.
　　Feng Z, Kim JH, Brady SF (2010) Fluostatins produced by the heterologous expression of a TAR reassembled environmental DNA derived type II PKS gene cluster. J Am Chem Soc, 132:11902-11903.
　　Kim JH, Feng Z, Bauer JD, Kallifidas D, Calle PY, Brady SF. (2010) Cloning large natural product gene clusters from the environment: piecing environmental DNA gene clusters back together with TAR. Biopolymers, 93:833-844.
　　Wu X, Yang D, Zhu X, Feng Z, Lv Z, Zhang Y, Shen B, Xu Z. (2010) Iso-migrastatin Titer Improvement in the Engineered Streptomyces lividans SB11002 Strain by Optimization of Fermentation Conditions. Biotechnol Bioprocess Eng, 15:664-669.
　　Lim SK, Ju J, Zazopoulos E, Jiang H, Seo JW, Chen Y, Feng Z, Rajski SR, Farnet CM, Shen B. (2009) iso-Migrastatin, migrastatin, and dorrigocin production in Streptomyces platensis NRRL 18993 is governed by a single biosynthetic machinery featuring an acyltransferase-less type I polyketide synthase. J Biol Chem, 284:29746-29756.
　　Feng Z, Wang L, Rajski SR, Xu Z, Coeffet-LeGal MF, Shen B (2009) Engineered production of iso-migrastatin in heterologous Streptomyces hosts. Bioorg Med Chem, 17:2147-2153.