暨南大学药学院导师介绍：王玉强

王玉强

性别： 男

籍贯： 山东

民族：汉

职称：教授   博导,硕导

学历：研究生

学位： 博士

电话： 020－85228481

电子邮件： yuqiang.wang@yahoo.com

简介： 　　 　　药物研究的第一步是发现有生物活性的化合物，然后是研究这些化合物的作用机理和药理活性。王玉强实验室主要从事治疗肿瘤、细菌和病毒、心脑血管系统、老年退行性疾病包括老年痴呆与帕金森和糖尿病等疾病药物的设计、化学合成及药理活性和作用机理的研究。 　　王玉强教授从事DNA-minor groove binding 药物CC-1065衍生物的研究近20年, 他的实验室合成了100多个CC-1065衍生物, 其中的YW-053是目前已知抗癌活性最强的少数化合物之一，其体外抗癌活性比临床应用的抗癌药物阿霉素强一百万倍 (J．Amer．Chem．Soc．117, 8917, 1995)。 　　王玉强教授在美国首次GMP合成治疗老年痴呆药物 memantine，作为核心成员，其团队在美国将memantine 成功开发。Memantine 2003年先后在欧美上市，2007年销售额达10亿美元, 正式成为“重磅炸弹”级药物。 　　王玉强实验室近年开展了对中药有效成份分子结构进行系统的化学修饰的工作。在中药穿心莲、川芎及丹参有效成份的结构修饰方面已卓有成效，发现了比天然产物疗效更高，毒性更低的新化合物。其中具有独特作用机理和良好治疗效果的糖尿病与脑中风两个新药已正式进入临床前研究。 　　王玉强教授1981年毕业于山东师范大学化学系, 获学士学位；1987年获美国 University  of Texas Health Science Center at Houston and M．D．Anderson Cancer Center博士学位。 随后进入美国耶鲁大学 (Yale) 医学院和加拿大阿尔伯特大学 (University of Alberta) 做博士后研究。九十年代初进入美国加州硅谷的生物医药公司从事药物的研究与开发，2005年回国任暨南大学教授，药学院院长，现任暨南大学新药研究所所长，博士生导师。2010年获广州经济技术开发区科技领军人才称号，2011年入选国家 “千人计划”专家, 2012年获广州市创新创业领军人才称号。 　　代表性论文 　　1．Wang, Y．; Farquhar, D．Aldophosphamide acetal diacetate and structural analogues: synthesis and cytotoxicity studies．J．Med．Chem．34, 197, 1991． 　　2．Wang, Y．; Liu, M．C．; Lin, T．S．; Sartorelli, A．C．Synthesis and biological evaluation of novel antitumor 3- and 5-hydroxy-4-methyl-2-formylpyridine thiosemicarbazones and their iron-chelates．J．Med．Chem．35, 3667, 1992． 　　3．Wang, Y．; Gupta, R．; Huang, L．; Lown, J．W．Synthesis and antitumor activity of CC-1065 functional analogues possessing different electron-withdrawing substituents and leaving groups．J．Med．Chem．36, 4172, 1993． 　　4．Wang, Y．; Huang, L．; Wright, S．C．; Larrick, J．W．Synthesis and antitumor activity studies of doxorubicin and DNA-minor groove binding oligopeptide conjugates．Gene 149, 63, 1994． 　　5．Fregeau, N．L．; Wang, Y．; Pon, R, T．; Wylie, W．A．; Lown, J．W．Characterization of a CPI-Lexitropsin Conjugate: Oligonucleotide covalent complex by 1H NMR and restrained molecular dynamics simulation．J．Amer．Chem．Soc．117, 8917, 1995． 　　6． Wang, Y．; Gupta, R．; Huang, L．; Luo, W．; Lown, J．W．Design, synthesis, cytotoxic properties and preliminary DNA sequencing evaluation of CPI-N-methylpyrrole hybrids．Enhancing effect of a trans double bond linker and role of the terminal amide functionality on cytotoxic potency．Anti-Cancer Drug Design 11, 15, 1996． 　　7．Wang, Y．; Yuan, H．; Ye, W．; Wang, H．; Wright, S．C．; Larrick, J．W．Synthesis and preliminary biological evaluations of CC-1065 analogs: effects of different linkers and terminal amides on biological activity．J．Med．Chem．43, 1541．2000． 　　8．Wang, Y．; Yuan, H．; Ye, W．; Wang, H．; Wright, S．C．; Larrick, J．W．Synthesis and preliminary biological evaluations of CC-1065 analogs: effects of different linkers and terminal amides on biological activity．J．Med．Chem．43, 1541．2000． 　　9． Wang, Y．; Wright, S．C．; Larrick, J．W．Synthesis and cytotoxicity of nitrogen mustard derivatives of distamycin A．Bioorg．Med．Chem．Lett．13, 461, 2003． 　　10．Wang, Y．; Ye, W．; Li, L．; Tian, Z．; Jiang, W．; Wang, H．; Wright, S．C．; Larrick, J．W．CC-1065 analogues bearing different DNA-binding subunits: synthesis, antitumor activity and preliminary toxicity study．J．Med．Chem．46, 634, 2003． 　　11．Wang, Y．; Yuan, H．; Wang, H．; Wright, S．C．; Larrick, J．W．Synthesis and preliminary cytotoxicity study of glucuronide derivatives of CC-1065 analogues．Bioorg．Med．Chem．11, 1569, 2003． 　　12．Wang, Y．; Li, L．; Jiang, W．; Larrick, J．W．Synthesis and evaluation of a DHA and 10-hydroxcamptothecin conjugate．Bioorg．Med．Chem．13, 5592–5599, 2005． 　　13．Wang, Y．; Li, L．; Jiang, W．; Yang, Z．; Zhang, Z．Synthesis and preliminary antitumor activity evaluation of a DHA and doxorubicin conjugate．Bioorg．Med．Chem．Lett．16， 2974-2977，2006． 　　14．Wang, Y．; Li, L．; Tian, Z．; Jiang, W．; Larrick, J．W．Synthesis and antitumor activity of CBI-bearing ester and carbamate prodrugs of CC-1065 analogue．Bioorg．Med．Chem．14, 7854-7861, 2006． 　　15．Wang, Y．; Eu, J．; Washburn, M．; Gong, T．; Chen, H．S．V．; Larrick, J．W．; Lipton, S．A．; Stamler, J, S．; Went, G．T．; Porter, S．The Pharmacology of Aminoadamantane nitrates．Curr．Alzheimer Res．3, 201-204, 2006． 　　16．Wang, Y．; Jiang, J．; Jiang, X．; Cai, S．; Han, H．; Li, L．; Tian, T．; Jiang, W．; Zhang, Z．; Xiao, Y．; Wei Wright, S．C．; Larrick, J．W．Synthesis and antitumor activity evaluations of albumin-binding prodrugs of CC-1065 analogue．Bioorg．Med．Chem．16, 6552-6559, 2008． 　　17．Sun, Y．; Jiang, J．; Zhang, Z．; Yu, P．; Wang, L．; Xu, C．; Liu, W．; Wang, Y． Antioxidative and thrombolytic TMP nitrone for treatment of ischemic stroke．Bioorg．Med．Chem．16, 8868-8874, 2008． 　　18．Guo, J-L．; Li, B-Z．; Chen, W-M．; Sun, P-H．; Wang, Y． Synthesis of substituted 1H-pyrrol-2(5H)-ones and 2(5H)-furanones as inhibitors of P．aeruginosa biofilm．Lett．Drug Design and Discov．6, 107-113, 2009． 　　19．Jiang, X．;  Yu, P．; Jiang, J．;  Zhang, Z．; Wang, Z．; Yang, Z．; Tian, Z．; Wright, S．C．; Larrick, J．W．; Wang, Y．Synthesis and evaluation of antibacterial activities of andrographolide analogues．Eur．J．Med．Chem．44, 2936-2943, 2009． 　　20．Zhang, Z．; Jiang, J．; Pei Yu, Zeng, X．; Wang, Z．; Larrick, J．W．; Wang, Y．Hypoglycemic and beta cell protective andrographolide analogue for diabetes treatment．J．Translational Med．7:62, 2009． 　　21．Xu, J．; Huang, S．; Luo, H．;  Li, G．; Bao, J．; Cai, S．; Wang, Y．QSAR studies on andrographolide derivatives as α-glucosidase inhibitors．Int．J．Mol．Sci．11, 880-895, 2010． 　　22．Wang, Z．; Yu, P．; Zhang, G．; Xu, L．; Wang, D．; Wang, L．; Zeng, X．; Wang, Y．Design, synthesis and antibacterial activity of novel andrographolide derivatives．Bioorg．Med．Chem．18, 4269-4274, 2010． 　　23．Sun, H．; Xu, L．; Yu, P．; Jiang, J．; Zhang, G．; Wang, Y．Synthesis and preliminary evaluation of neuroprotection of celastrol analogues in PC12 cells．Bioorg．Med．Chem．Lett．20, 3844-3847, 2010． 　　24．Zeng, X．; Liu, X．; Liang, H．; Bian J．; Pei, G．; Dai, H．; Polyak, S．W．; Song, F．; Ma, L．; Wang, Y．; Zhang, Z．Synergistic effect of AL-1 and various antibiotics on the formation of biofilms and production ofexopolysaccharide and pyocyanin by Pseudomonas aeruginosa．Antimicrob．Agents Chemother．55, 3015-3017, 2011． 　　25．Lu, X．; Wan, S．; Jiang, J．;  Jiang, X．; Yang, W．; Yu, P．; Xu, L．; Zhang, Z．; Zhang, G．; , Zaijun Z．; Shan, L．; Wang, Y．Synthesis and biological evaluations of novel apocynin analogues．Eur．J．Med．Chem．46, 2691-2698, 2011． 　　26．Sun, Y．; Yu．; Zhang, G．; Wang, L．; Zhong, H．; Zhai, Z．; Wang, L．; Wang, Y．Therapeutic effects of tetramethylpyrazine nitrone in rat ischemic stroke models．J．Neurosci．Res．90, 1662–1669, 2012． 　　27．Sun, Y．; Zhang, G．; Zhang, Z．; Yu, P．; Zhong, H．; Du, J．; Wang, Y． Novel multi-functional nitrones for treatment of ischemic stroke．Bioorg．Med．Chem．20, 3939–3945, 2012． 　　28．Yu, P．; Xia, L．; Zhao, J．; Zhang, G．; Zhang, Z,; Lang, M．; Wang, Y． Synthesis and preliminary anticancer evaluation of 10-hydroxycamptothecin analogs．Biol．Pharm．Bull．35, 1295–1299, 2012． 　　29．Ma, Li．; Liu, X．; Liang, H．; Che, Y．; Dai, H．; Yu, K．; Liu, M．; Ma, L．; Yang, C-H．; Song, F．; Wang, Y．; Zhang, L．Molecular targets of 14-alpha-lipoyl andrographolide on quorum sensing in Pseudomonas aeruginosa．Antimicrob．Agents Chemother．(Online July 16, 2012)． 　　30．Cui, G．; Hung, M．; Shan, L．; Lei, S．; Choi, I．; Zhang, Z．; Hoi, M．P．; Yu, P．; Wang, Y．; Lee, S．M．A novel danshensu derivative confers cardioprotection via PI3K/Akt and Nrf2 pathways．Intl．J．Cardio．2012 (in press)． 　　 　　联系方式： 　　电话：(020) 8522-8481;  Email: yuqiang.wang@yahoo.com

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